Neuroendocrine differentiation of prostate cancer.
نویسندگان
چکیده
Global Objectives: Review recent advances in the identification and diagnosis of current and emerging disease states. Discuss the pathophysiology of various disease states and the multidisciplinary considerations that affect patient care outcomes. Identify recent changes in requirements for accreditation, licensing, and regulatory compliance in across all divisions of pathology. Discuss recent developments in scientific research and their application to the practice of pathology and laboratory medicine. Discuss recent developments in diagnostic technologies and their application to the provision of enhanced laboratory services.
منابع مشابه
Evaluation of Neuroendocrine and Proliferative Markers in Prostatic Adenocarcinomas
Background: Certain marker studies have practical importance in the biology of prostate cancer. The purpose of this study was to determine whether the quantification of certain neuroendocrine and proliferative markers obtained during transurethral resection or prostatectomy, would help in the prognostic evaluation of prostatic adenocarcinomas. Methods: The present study was performed on samples...
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Neuroendocrine differentiation (NED), which is not uncommon in prostate cancer, is increases in prostate cancer after androgen-deprivation therapy (ADT) and generally appears in castration-resistant prostate cancer (CRPC). Neuroendocrine cells, which are found in normal prostate tissue, are a small subset of cells and have unique function in regulating the growth of prostate cells. Prostate can...
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The prognostic significance of neuroendocrine differentiation in prostatic malignancy is controversial, but the results of recent studies with markers such as chromogranin A and neurone-specific enolase suggest that neuroendocrine differentiation, as reflected by increased tissue expression or blood concentrations of these neuroendocrine secretory products, is associated with a poor prognosis, ...
متن کاملNeuroendocrine differentiation in prostate cancer.
As any organ in the body human prostate is composed of many different types of cells as well as extracellular components. During prostate development, reciprocal cellular interactions between stromal cells and prostate epithelial cells ultimately lead to the development of a mature prostate. Normal prostate is composed of repeating cellular units that contain stromal and epithelial compartments...
متن کاملNeuroendocrine differentiation of prostate cancer: a review.
Neuroendocrine cells are one of the epithelial populations in the prostate. Neuroendocrine differentiation (NED) has been observed in prostate cancer. In addition to small cell neuroendocrine carcinomas and carcinoid tumors of the prostate, prostatic adenocarcinomas may have NED. The incidence and clinical relevance of NED in prostatic adenocarcinoma is not clearly understood because of conflic...
متن کاملImmunohistochemical Assessment of Neuroendocrine Differentiation in Colorectal Carcinomas and Its Relation with Age, Sex, Grade Plus Stage
Background and Objective: Neuroendocrine differentiation has not been proved to have effects in behavior of colorectal carcinomas. The aim of this study was Immunohistochemical evaluation of neuroendocrine differentiation in colorectal cancer. Patients and Methods: In this cross-sectional study, 83 paraffin blocks from patients admitted in Rasoul-e-akram Hospital, Tehran, Iran, during 2003 to ...
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ورودعنوان ژورنال:
- Asian journal of andrology
دوره 15 3 شماره
صفحات -
تاریخ انتشار 2013